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J Minim Invasive Spine Surg Tech > Volume 10(1); 2025 > Article
Krishnan, Aryal, Degulmadi, Mayi, Rai, Dave, Anil, Mikeson, Agrawal, Murkute, and Dave: A New Classification System for Reporting Complications of Percutaneous Transforaminal Endoscopic Lumbar Decompression

Abstract

Transforaminal endoscopic lumbar discectomy (TELD) is increasingly used as an effective alternative to open discectomy or microdiscectomy, supported by comparable outcomes in the literature. Advances in techniques and instrumentation now permit selective endoscopic decompression of diverse disc pathologies, including complex stenosis cases. However, the rising number of procedures has been accompanied by a corresponding increase in complications, which has been exacerbated by heterogeneous reporting standards in literature. Standardized systems for defining, classifying, and scoring TELD complications are lacking, but would be essential for quality assurance, comparative studies, research, and outcome assessment. Therefore, we systematically reviewed the literature to identify studies focusing on TELD complications and propose a consensus classification system. PubMed, Scopus, and Science Direct were searched to identify studies primarily addressing complications, or their classification, in patients with lumbar disc herniation or lumbar canal stenosis undergoing TELD. The exclusion criteria encompassed studies involving other pathologies, such as infections or tumors, and studies with patients undergoing revision surgery. Initial database searches yielded 887 articles, with 560 unique articles after duplicate removal. Title and abstract screening excluded 313 articles, leaving 247 articles for full-text assessment. Ultimately, 95 articles met the inclusion criteria. The narrative synthesis focused on compiling complications associated with TELD, which helped propose a structured classification system. Complications in TELD can match or exceed those of traditional surgical procedures, influenced by a steep learning curve and longer initial operation times. Expanded indications introduce the potential for encountering previously unreported complications even among experienced surgeons. Effective documentation, rating, and follow-up of complications are crucial for informed treatment decisions, enhancing patient consent processes, and improving overall outcomes.

INTRODUCTION

Lumbar disc herniation (LDH) is one of the most common pathologies encountered by spine surgeons in their clinical practice. Microdiscectomy is still considered the gold standard treatment for those cases that need surgical management [1,2]. Nowadays, the paradigm is shifting towards endoscopic management. Transforaminal endoscopic lumbar discectomy (TELD) is an effective alternative to open or microdiscectomy, and with literature evidence of similar results of endoscopic discectomy, the indications have expanded [3,4]. Remarkable technical and instrument evolution now enables selective endoscopic decompression of nearly all types of discal pathology, including the conventionally forbidden pathologies like central, calcified, migrated and axillary LDH as well [5-9]. Moreover, the indications for this technique are becoming broader, ever-evolving and crossing over to the complex domains of stenosis [5,10,11]. TELD is known to standout over other approaches of endoscopic spine surgery in terms of respecting the anatomy of the posterior elements of the spine the most, and the capability of being performed under local anesthesia (LA) [12,13].
Increased adaptation, new concepts of pain generators and targeted approach is giving unpredictably good outcome [14]. Although the technique has evolved remarkably, successful TELD requires techniques, which are tailor-made to remove the herniated disc fragments in various types of LDH [5]. Moreover, as the number of spine surgeries being performed with this technique has increased, many related and rare complications have also emerged [15]. Much of the complications of TELD are not different from those of spine surgery in general. Nonetheless, TELD also has its own set of complications, due to a different approach and the involvement of different structures, instruments, fluid medium, etc. The reporting of complications of TELD has been done in the literature in the past, with some authors even trying to classify the complications [16-18]. Complications have been classified as intraoperative or postoperative, early or late, based on severity, and so on [16,18,19]. Some researchers have reported them as unique and rare complications [20]. However, there has been a heterogeneity in the way the complications of TELD have been reported. Currently, there are no satisfactory systems for defining, classifying, and/or scoring TELD complications, although it would be important for quality assurance, comparative studies, research and outcomes.
Here, we present a systematic review of the literature to identify the relevant articles that primarily focus on the reporting of complications in TELD. We have described the complications of TELD by compilation of evidence gathered from this review. Lastly, we aimed to give a consensus on a comprehensive classification system of complications in transforaminal endoscopic lumbar discectomy/decompression, which surgeons can adopt in their clinical practice.

MATERIALS AND METHODS

A thorough systematic review of 3 databases, namely PubMed, Scopus, and Science Direct, was done to identify the relevant articles that discussed the complications of TELD. We followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) 2009 guidelines for the literature search [21]. We included those studies whose primary focus was the management of patients with LDH or lumbar canal stenosis (no restriction regarding age, race, nationality, or gender) via the TELD approach. The preoperative, during the surgical procedure and postoperative complications were reported as one of the main outcomes. Randomized and non-randomized controlled trials, retrospective, prospective, or concurrent cohort studies, cross-sectional studies, case series and case reports were included if the focus was on complications and its classification included without bias. We also included those review articles, where the description of the complications of TELD was the focus. The articles from the inception of the databases to 22nd February 2024 were screened. Only the literature published in the English language originally and those available with English translations were considered for review.
We excluded those articles that focused on patients who underwent intervention by any other surgical method, TELD for other pathologies such as infections or tumors, patients with spondylolysis, spondylolisthesis or instability, and those undergoing revision surgeries. Studies with no/poor records of preoperative and postoperative data, improper selection criteria, inaccurate data reporting, no diagnostic data or no follow-up were also excluded. All unrelated, those with only abstracts, and articles whose full-text was not available were excluded.
A standard search strategy was used in PubMed, then later modified according to each specific database. Search strategies were constructed to include free-text terms and any appropriate subject indexing (e.g., medical subject heading, MeSH), with the use of Boolean search strings (AND, OR, NOT) to retrieve eligible studies. The keywords used were percutaneous, transforaminal, endoscopy, endoscopic, endoskopic, discectomy, diskectomy, and complication. The detailed search strategy used in all 3 databases has been provided in Table 1. In the comparative articles with other methods of discectomy, only complication related data and material was studied.
All searched data was collected into a reference management library, and duplicates were deleted. References remaining after this step were exported to an Excel file with essential information for screening. These were the authors’ names, publication year, journal and abstract. Two independent reviewers screened the titles and abstracts for eligibility of inclusion based on our criteria. Any disagreement was either resolved through discussion or by consensus, with the opinion of another senior author. In addition to studies identified from the databases searched, all reference lists from these articles studied were analyzed for the potential inclusion of additional relevant articles. A second round of screening was conducted by both reviewers, reviewing the full-text of the remaining articles. Only articles pertaining to TELD discussing the complications were included by consensus. Reviewers kept a log of excluded studies, stating the reasons they were omitted. No study authors were contacted through any source of communication.

RESULTS

The preliminary search of the databases yielded a total of 887 articles. Additionally, we identified 16 articles through the relatable old database of the authors library and also from coauthors’ previous experience on the study of the complications of endoscopic lumbar spine surgeries. After removal of duplicates, 560 articles remained for review. The screening of titles and abstracts of these articles helped us exclude 313 articles. The full-text of the remaining 247 articles were assessed for eligibility of inclusion. Ninety-eight articles reported “no major complications” so were excluded. Forty-three articles were excluded as they did not primarily focus on discussing the complications of TELD. Eleven articles were excluded as they were not relevant to our topic. Finally, 95 articles were included for the review (Figure 1).
A narrative synthesis of the results was done, with a focus on the complications associated of TELD. In an effort to provide a complete overview, a comprehensive classification of these complications was attempted.

DISCUSSION

In time TELD has proved to be one of the most efficient methods in the field of endoscopic surgery. It is distinctly recognized for its advantages in form of minimum soft tissue damage, direct visualization of the pathology, magnification, better illumination, possibility of use of LA, less postoperative pain, early postoperative mobilization, and day care surgery [22,23]. Several studies in literature have already reported that TELD is also has either similar or even a lower complications rate [1,24]. But with more widespread use in advanced pathologies of LDH, stenosis and degenerative disorders, there are going to be more failures and complications, alike with any technique of spine surgery. Unique complications like passage of the working channel through the spinal canal into the disc space, instrument breakage, intradural migration of disc etc. with serious consequences have been reported [20,25]. In a multicentric study of over 26,000 cases, the overall complication rate of TELD was less than 1%: (1) dysesthesia 0.45%, (2) cerebrospinal fluid (CSF) leak 0.17%, (3) discitis 0.25%, (4) motor or sensory loss 0.32%, and (5) recurrence 0.79% [26]. Another review including over 10,000 cases indicated a failure rate of 4.3%, incomplete removal 2.8%, recurrence rate 0.8%, persistent pain 0.4%, and approach-related surgical site pain 0.2% [27]. Nevertheless, there are several technical guidelines recommended and they are evolving to increase the safety or effectiveness of TELD and reduce/prevent complications [28,29].
This study contains consolidated evidence from the literature, which focuses mainly on the reporting of the complications, which was the main aim of this study. The commonest complications in the TELD are dural tear, recurrence, nerve injuries such as motor weakness, nerve irritation, transient paresis, postoperative dysesthesia, vascular injury, broken instrument, hematoma, infection, incomplete removal, failure and so on [16]. Below the details mentioned are completely made on different aspects of the articles. Majority of complications reported are recoverable such as dural tear, infection, broken instrument (should be removed immediately), nerve injuries (takes longer duration to resolve but are recoverable), artery injury, hematoma, abscess. Recurrence and failure requires reoperation [30]. Recurrence is also classified as late recurrence and early recurrence depending on the duration gap at which the recurrence occurred [31,32]. Zhu et al. [18] is the only author who has reported death (2 patients). Seizure can be a life threatening condition in this technique as the seizure starts with neck pain and in case of onset of neck pain in the start or the middle of the surgery, some authors suggest that the surgery should be stopped [33].
Classifications in the literature: Clavien et al. [34] came up with the classification of complications in surgery. It is a comprehensive classification of surgical complications, based on their severity or impact on the patient/outcome. This complication was adopted by other surgical disciplines as well in due course of time, including spine surgery [35-38]. Lewandrowski [17] applied this classification to TELD. Kim et al. [16] have classified complications in TELD based on relation to the timeline, i.e. intraoperative and postoperative (early and late). Zhu et al. [18] classified the complications based on the frequency and severity into the most common, the most severe and the rarest complications. The largest published series to date, focusing on complications of TELD, was by Choi et al. [27], including 10,228 patients.
It is not always an easy task to classify the untoward incidents or outcomes in TELD, as they are often a spectrum of failed procedure, sequelae and complications [39]. Failure is when the objective of the procedure is not met on the first hand, for e.g., failure to remove the herniated disc or decompress the stenotic foramen. A sequela is a known aftereffect inherent to the procedure, such as operative site pain or nerve root edema. Complications are the untoward incidents that lead to deviation from ideal course of the management, that may impair or delay the recovery and may warrant additional diagnostic or therapeutic measures. Also, there is an overlap between timelines of occurrence of complication. For example, an intraoperative complication can have an additional effect in the postoperative period like intraoperative bleeding leading to hematoma, pain, and deficit postoperatively. There has been a paucity of literature regarding on articles published which describe a proper classification of the complications. It is important to classify complications because of the underreporting and to describe the cause and proper prevention method. It will help in identification of identifying names, types of complications, also it will help to understand and identify the relevant data.
The complications can occur before the surgery (pre-emptive due to anesthetic and pharmacological agents). They may occur when a surgeon approaches the area of work, during the execution of steps of the surgery, or after the surgery. The after effects can again appear immediately, after some time, or sometimes late. It is apparent that the complications of TELD can be classified based on timeline, as well as in relation to the various steps of the surgery. Below is a comprehensive classification the authors have come up with, that merges both (Table 2).

INTRAOPERATIVE COMPLICATIONS

1. Approach-Related

1) Pain

Irritation of the exiting nerve root causes approach-related new root pain [40]. When noted, the surgeons should promptly try to adjust the entry point and trajectory and try to land more caudally in the foramen. The traditional teaching is to walk down the facet with the needle [41]. Reduced height of the foramen/disc is a risk factor. The use of sequential dilators is another requisite in these cases instead of directly applying the tapered dilator. Surgeons should never directly target the upper half of the disc to avoid an exiting root injury. Remain in the lower part of the foramen, and the guide wire should always be followed by the dilator and working cannula as closely as possible to the facet joint [42]. Patient may also have pain if the instrument manipulates or the radiofrequency (RF)/laser/bipolar comes in contact with the traversing nerve root. Either conversion to general anestheia or abandoning the procedure could be the options if the pain persists [43]. TELD may be converted to open surgery or alternatives for sensitive patients in spite of counselling or approach related exiting nerve root pain. In addition, low tolerance to pain and anxiety can make the procedure nonexecutable. Counselling the patient preoperatively, including demo videos or self-help groups, would reduce the anxiety. As patient is conscious, explanation step by step may be needed. The obturator guiding method is another method to have precise control and reduce attempts [44].

2) Vascular injury

Bleeding due to injury to vascular structures is a big hinderance in TELD, especially when profuse. The potential sources of bleeding during TELD are epidural vessels, foraminal artery, segmental lumbar artery or rarely, the great vessels [45,46]. Judicious use of bipolar or RF ablation solves most of the issue. It is more in epidural techniques and when bone sculpting is done [47]. Laser can be helpful along with RF. Pressure saline is an adjunct. Reinsertion of the trocar and waiting for a while does help with tamponading. Cold saline and adrenaline in saline irrigation can be used [41].

3) Visceral injury

The abdominal and the retroperitoneal structures may be injured during TELD. The needle can perforate the peritoneal sac or the colon before landing at the foraminal target, if the skin entry point is chosen too far laterally in tangential entry to disc or the trajectory is kept vertical [48]. Inadvertent advancement of a needle or other instruments beyond the anterior or anterolateral disc margin after reaching the disc can also occur, especially when TELD is being done to treat primary early spondylodiscitis or postoperative spondylodiscitis with soft annulus [18,49]. Ureter or bowel injury has been reported in the literature [50]. To avoid these inadvertent complications, the needle or instrument position should be repeatedly confirmed on fluoroscopic views especially during early learning. Remember, the anteroposterior image view is our directional guide, and the lateral image is our depth guide. The needle tip should never have crossed ventral to the intertransverse plane or facet joint complex plane till it has touched the facet.

4) Wrong-level surgery

Although fluoroscopic guidance is used while approaching the target level, the markings and entry are done on the surface/skin [51]. The needle may land up on an adjacent level due to the lordotic nature of the lumbar spine leading to surgery at the wrong level [52]. Confirmation of the correct level is therefore essential after every step of approach, so to prevent this misfortune. In addition, presence of transitional vertebra or a variation in number of vertebrae may cause a discrepancy between the level reported on the magnetic resonance imaging (MRI), which may not correspond to the x-ray/fluoroscopic localization [53].

2. Execution-Related

1) Dural injury

The one of the most common complications of TELD is an intraoperative dural breach or traversing root sleeve injury. The prevalence of inadvertent dural sac tears during open LDH surgery is variable, ranging from 1.8% to 17.4% [54]. Because of the surgery with irrigation solution, it is difficult to detect a dura sac tear during TELD. Most cases may go unnoticed and asymptomatic. A mechanical tear caused by the needle, guidewire or the instruments, or a direct/indirect thermal injury caused by bipolar/laser/RF is the reason for dural injury. If dural injury is unrecognized or untreated, in some cases serious neurological deficits may develop. Most dural tears are usually self-sealing due to tamponade effect [55]. However, a neural tissue injury is not pardonable. If rootlets herniate through small rents, it can create deficits or new pain. If a dural tear is noticed and if the surgical objective is already achieved, then observing the patient should be the protocol [56]. The redundant position of the rootlets getting sedimented in supine position may also be a reason what author believes for nonsymptomatic or under reported dural tears. Repeat transforaminal approach through scope and packing of the area with SurgiSeal (Nitcho Kogyo, Tokyo, Japan) or gelatine sponge bits have been successfully tried in liquor leaking wound with additional external stitch where there were no neurological problems. Otherwise, if in the postoperative period, any leak or symptom is noted with an MRI justification, it should be explored. If any nerve rootlets herniate from the split and get strangulated, severe radicular pain starts [55]. If the surgical objective is pending preoperatively, TELD should be abandoned and converted to open surgery. Open surgical protocols for dural injury management have to be followed in such cases [57]. For preventing intraoperative dural breach, surgeons should be vigilant while working near the blind spots where the endoscope does not provide adequate visualization [58].

2) Neurologic injury

The neural structures at risk of injury during TELD are traversing nerve root, exiting root/dorsal root ganglion (DRG) and furcal nerves. A deviation of the needle, dilator and cannula to the upper part of neural foramen should be avoided as it can injure the exiting root/DRG [59]. It is better to keep the beveled open face of the working sheath towards the cranial side till it has entered the disc while rail-roading on the obturator-dilator. After entering of the sheath into the annulus, it can be rotated to face the bevel dorsally. This can again prevent trapping of exiting nerve root by the leading edge. The target should always be the lower half of the foramen [29]. A detailed preoperative MRI evaluation is needed to understand the low exiting (horizontal) nerve root anatomy. Preoperative distance measurement of exiting nerve root to facet at the lower disc level in axial MRI helps to avoid exiting nerve root injury. Similarly, parasagittal and axial magnetic resonance images can detect a horizontal root or low exiting root/conjoined roots, which is a strict contraindication to the inside-out technique [60]. A longer duration of surgery with the scope at an angle close to the horizontal plane can cause a constant strain on the exiting root and add to the woes, leading to postoperative dysesthesia or paresis. The traversing root and the thecal sac are at a risk of injury with blind or excessive intraoperative manipulation by instruments. Initial landing should be as close to the target as possible. The target point and approach angle can be adjusted according to the zone of herniation, type, migration, basic technique used and LDH level. Visualized controlled work under endoscopic view is to be done. Outside-in technique with the use of rotatory instruments and nonvisualized blind reamed foraminoplasty increase the chances of injuries to the traversing root and the thecal sac if not judiciously done. Likewise, steerable instruments also can cause injury when working away from nonvisualized areas.

3) Instrument failure

As the instruments used in full-endoscopic spine surgery are thin, low profile, they are not as sturdy as the ones used in open or minimally invasive spine surgeries. To add to this, TELD instruments have a long lever arm and may also be articulating, so the chances of breaking are more [61]. Gentle and careful handling of the instruments is recommended. The surgeon should use the working cannula or the scope as a joystick to change the direction of work, instead of applying undue force on the instruments.

4) Reaction to contrast material

Nonionic contrast materials such as iohexol (Omnipaque, GE Healthcare, Princeton, NJ, USA) is often used to confirm proper needle position in the Kambin triangle before proceeding further. This is more so in the early phase of the learning curve. Although the safety of nonionic contrast media have been widely reported in the literature, they are notorious in causing sporadic episodes of adverse reactions, urticaria, nausea, flushing, headache, hemodynamic abnormalities, arrhythmia, and seizures [62,63]. The use of contrast agents can be minimized once sufficient experience is gained, and omitting the routine practice of discography [64]. Indigo Carmine is a blue-colored dye which is used to help identify degenerated disc tissue during endoscopic discectomy. It differentially stains the disintegrated disc material, guiding the surgeon as to what is to be removed during the procedure. There have been reports of hemodynamic alterations after injecting indigo carmine into the disc space, such as hypotension, tachycardia, cardiac dysrhythmias and, in the worst-case scenario, anaphylaxis [65]. The anesthetists should be informed during the step of dye injection into the disc so that they can be more vigilant to the hemodynamic parameters of the patient and respond quickly if any reaction occurs. With experience, surgeons could skip this step altogether to avoid potential hazards.

5) Iatrogenic bony injury/instability

With the extended indications, TELD often involves bony work. The surgeon, at times, has to drill the facet, pedicle or the posterior vertebral wall. This is more so when dealing with cases of high migrated discs, axillary LDH, and stenosis [66]. A coronal facet orientation, especially at the L5–S1 level requires the drilling of the facet for access. In cases of low iliac crest, a shallow transforaminal approach is still possible. However, in cases of high iliac crest, a modified technique with a more medial placement of the skin entry and endoscopic visualized resection of the superior facet tip is be done [67]. Inadvertent excess bony work may lead to injury to the facet or fracture of the pars, causing intraoperative bony instability.

6) Failure/missed fragment/incomplete decompression

Failure occurs when the primary objective of the surgery is not fulfilled. Failure to remove the herniated disc or incomplete decompression of the stenotic area is quite common especially in early learning curve [68,69]. It occurs because of a residual or complete fragment remaining as the cause of compression. The patient may have an immediate pain-free period for a day or two under the LA influence or steroid and again get the same pain back. The patients usually have radicular pain without a significant pain-free interval. A typical finding is restricted straight leg raise. This is more likely to occur in cases of migrated LDH, axillary fragment or large central LDH with high canal compromise. At times, a sequestered disc fragment may migrate from its original position and the surgeon may not find it at its corresponding position on MRI. A change in the location of the fragment after the initial presentation can only be confirmed by an immediate preoperative screening MRI or X-MRI [70]. A concomitant lateral recess/central stenosis, dynamic stenosis or instability frequently adds to advanced failed cases [71]. Lateral recess bony stenosis can be addressed with a separate decompression procedure. In cases of unilateral symptoms of long-standing and moderate stenosis, TELD with stenosis decompression is gaining momentum and advances are being reported [72]. Another conceptual change is to understand that the disc prolapse material can have associated end plate cartilage or/and annulus in addition to nucleus fragment. This may have to be removed for complete decompression especially with acute on chronic clinical history. There may be small to big end plate junction failure or posterior rim apophysis fracture [73,74]. This may be healed or avulsed nonunited and may necessitate removal when needed. Incomplete decompression can also occur due to technical difficulties. To prevent this problem, proper training, multiple instrument inventory, variable techniques and tricks are needed with progressive learning. Technically, either you must reach the base of herniation in front of the endoscopic view, or you have to have steerable instruments under vision to be used. Adequate knowledge of anatomical relationships is an essential know-how. Plotting the fragment on plain anteroposterior and lateral projection radiographs helps determine the target point. Moreover, the ability to recognize the endpoint of the decompression is the crux for a successful TELD [75]. The endpoint may vary depending on the situation. Not all signs are always possible and thus, the surgeon should make a judicious call based on experience.

7) Seizures

Seizures can be caused by inadvertent administration of the contrast media into the thecal sac during TELD [76]. Otherwise, intraoperative seizures are due to increased epidural pressure, although their occurrence is rare (0.02%) [77]. The duration of the procedure, speed of saline infusion and use of large channel endoscopes are the major risk factors that should be optimized. Prolonged duration of surgery also can precipitate prodromes and seizures. Other factors include hypoxia, a history of epilepsy, anesthetic and sedative agents, etc. [33]. Mechanical irrigator system maintain constant pressure, but can be dangerous if not used judiciously. Instead, manual irrigation (drip stand elevation and cuff pressure) is intermittent and allows washing out excess fluid. Also, a high index of suspicion and early recognition of the prodromal symptoms like neck or upper back pain, headache confusion, visual disturbances, hemodynamic abnormalities and discomfort is the key to avoid seizures [33].

3. Anesthesia/Sedation-Related

TELD under LA can be challenging for surgeons in their early learning curve due to poor patient tolerance and discomfort [78]. General anesthesia (GA) provides a better surgical experience in such cases. Also, the secure airway and controlled conditions make the anesthetist’s life easier. However, if performed in GA, TELD can also invite all types of complications of GA [79]. Most cases of TELD today are done under LA and conscious sedation. The common drugs used for sedation are midazolam, fentanyl, dexmedetomidine and/or propofol. Adverse reactions to each of these drugs can occur. Preoperative intramuscular injection of morphine (5 mg) could reduce the patient’s pain except for a higher incidence of nausea and vomiting [80]. It has longer duration of effect than fentanyl. Opioid-induced hyperalgesia, a state of nociceptive sensitization after previous exposure to opioids, is an important issue [81]. This will end up in increased requirement but less likely to be a problem in Indian subcontinent. Propofol, the most widely used sedative drug for its rapid onset and offset, can induce sedation but cardiorespiratory depression is a problem [82]. Midazolam, a benzodiazepine, can produce sedative, hypnotic, anxiolytic, and muscle relaxant effects. Compared with propofol, midazolam has lower incidence of cardiorespiratory depression and is much safer due to this advantage [80]. However, vasovagal shock can occur. Toxicity and allergy to bupivacaine or lignocaine can occur that is dose dependent [83]. Standard TELD was performed under LA by the pioneers. Due to the high safety and tolerability for patients it is the standard. LA has little disturbance to the patient’s respiratory, circulatory, and other systems [84]. Foraminoplasty is expanding the application of TELD. However, it needs increase in the LA as well as intravenous supplementary drug doses. Due to these all possible and probable issues, a professional anesthetist is a must during TELD [5].

POSTOPERATIVE COMPLICATIONS: IMMEDIATE POSTOPERATIVE

1. Approach-Related

1) Postoperative dysesthesia

The most common neural injury problem is approach-related irritation of the foraminal/extraforaminal neural structures (exiting nerve root, DRG, or frucal nerve) or lateral recess structure (traversing nerve root) [85]. Irritation injury can be a neuropraxia, axonotmesis or neurotmesis and can be caused by the approach needle, obturator, the working cannula or hand instruments during the approach steps. If neural injury occurs in the conventional posterior open discectomy, it may usually occur to the traversing nerve root, which is already compromised. So, accentuation of any numbness or dysesthesia is explainable and patient can get convinced. However, in TELD afresh DRG can be the injured one, and the patient has new symptom called postoperative dysesthesia (POD) [86]. POD may cause significant sequelae and is common and reported in various series up to 15% patients, especially at the upper lumbar levels [40]. Transient paresis may occur, with estimated incidence rate of up to 4% reported in the literature [18]. The risk factors are foraminal or far-lateral disc herniations, narrow foramen, and more horizontal position of the working tube. This complication is particularly stressful for the surgeon, because the symptoms differ from the patient’s preoperative symptoms. Blind reamed foraminoplasty for “outside-in” approach will have more POD than visualized endoscopic foraminoplasty [42]. Widening of approach triangle without taking adequate care for foraminoplasty and especially for advanced fusion indications with expandable cage also have more incidences of POD. During the procedure, patients are conscious but under LA. Patient feedback gives you the indication to redirect and reconsider the approach direction. But, if excess LA is given then you may get lesser feedback and a GA, if used can be very dangerously compounding, though used at many centers. Neuromonitoring can be used in GA [87]. A continuous palpation of leg muscles throughout the procedure by a physiotherapist or physician is also a naive method to detect abnormal neural contractions while manipulating. Although common and disabling, POD recovers in most patients after several weeks or months without additional therapeutic measures [18].

2. Execution-Related

1) Postoperative pain

Regardless of complete removal of LDH, persistent pain can be there postoperatively. Various possibilities should be kept in mind in such cases:

(1) Residual disc fragment

When some disc fragment is not removed completely, the patient may still have pain postoperatively. The key step of TELD is to position the working channel/endoscope tip near the herniated mass. It can be aimed from the starting (outside-in) or achieved as you work through (inside-out) or use steerable instruments. An axillary type of disc herniation is a common cause of incomplete removal of herniated disc material and thus, failures [68]. If it is a calcified disc or combined with severe stenosis, TELD and removal could be limited to most experienced surgeons.

(2) De novo disc prolapse

This terminology is given to the process where iatrogenic new disc herniation occurs during the index procedure [16]. It has been attributed mostly to the inside-out technique. It may occur with steps such as the intradiscal injection of the dye/LA or when hammering the trocar or cannula into the disc, with a prevalence of 0.2% [88]. It is there recommended that intradiscal dye or LA, if used, should be injected very gently, and a serial dilation with progressively increasing sizes of dilators should be adopted before inserting the obturator and working cannula.

(3) Nerve root edema

A compressed or inflamed nerve root may be edematous. Moreover, intraoperative handling of the root may add up to the aggravation of this edema. A nerve root edema may last longer and trouble in some cases [27]. Management usually remains conservative, with observation oedema reducing medicines and anti-inflammatory agents.

(4) Herniated rootlets from a dural rent

Unrecognized dural rent during surgery may present postoperatively with severe pain due to strangulation of rootlets that could herniate from such unrepaired openings [55]. Such cases warrant urgent re-exploration, preferably with open microscopic surgery [57].

(5) Iatrogenic segmental instability

An unrecognized bony injury during excessive drilling of the facet, pedicle or the posterior vertebral wall may present postoperatively with pain due to iatrogenic instability [66]. It is wise to address a concurrent lateral recess stenosis with a separate posterior procedure to avoid inadvertent excess bony work which may cause injury to the facet or fracture of the pars [89].

(6) Epidural hematoma

Epidural hematoma can develop from the venous plexus, epidural or foraminal vessels, or due to persistent bleeding from cancellous bone when bony work has been done [27]. Although the incidence of symptomatic epidural hematoma is low, revision surgery may be needed for extensive epidural hematoma [28,90]. Proper history about oral anticoagulants needs to be taken always and stopped 3 days prior. It is ideal to achieve absolute hemostasis in the epidural space using bipolar or RF and also in the soft tissue planes. In authors’ experience, keeping the trocar in situ for a few minutes or packing the tract with gelfoam helps.

(7) A misdiagnosis of hip, knee, or peripheral nerve pathology etc. should be reconsidered if no obvious reason for postoperative pain could be isolated [24].

2) Neurologic deficit

Although the occurrence of gross neurologic deficit is rare in TELD, it is one of the dreaded complications of this procedure [18]. The traversing nerve root is at a risk of injury with the instruments or the bipolar RF/laser. Even a large, herniated disc can injure the nerve root during its extraction. Unrecognized dural tears may also lead to postoperative neurologic deficit [55]. In case of severe neurological deficits such as foot drop or cauda equina syndrome, open surgery and exploration are recommended.

3) Extravasation of irrigation fluid

Since TELD is a fluid medium based surgery, there is a risk that the irrigation fluid may seep into the tissue planes. Extravasation of irrigation fluid has been reported to occur in upto 3.8% patients [71]. Most cases are self-limiting and require only observation. Limiting the surgical time minimizes this complication.

4) Pneumocephalus

Pneumocephalus is a condition in which air enters into the subdural or subarachnoid space. Although TELD is a closed fluid-medium surgery, there is a rare possibility that in a case of inadvertent dural tear, pneumocephalus may occur. The mechanism is that a sudden gush of CSF out of the dural sac creates a negative intrathecal pressure, and any air trapped in the working channel or working cannula may get sucked into the thecal sac and migrate cranially [91]. Symptoms may range from headache, dizziness, nausea, and vomiting to more severe features including drowsiness, confusion, disorientation, agitation and seizures [92]. A reverse Trendelenburg position (head-low) should be adopted in case a dural rent occurs to prevent air from entering into the thecal sac.

3. Anesthesia/Sedation-Related

1) Transient paresis

In most cases it occurs because of the use of LA and therefore resolve themselves shortly after surgery which leaves no residuals but adds to the patient and the surgeon’s anxiety.

2) Urinary retention

Zhu et al. [93] reported urinary retention as a result of epidural anesthesia, which is a very rare complication in TELD. It can be managed with catheterization, observation and catheter removal following the reappearance of bladder sensations.

3) Adverse Drug Reactions to Anesthetic Agents/Opioids/Sedatives (Can Occur Late Also).

POSTOPERATIVE COMPLICATIONS: EARLY POSTOPERATIVE

1. Approach-Related

1) Retroperitoneal hematoma

The occurrence of hematoma is relatively rare, but a retroperitoneal hematoma or epidural hematoma can develop. Injury to segmental artery or lumbar radicular artery or their branches during the transforaminal approach or extraforaminal discectomy may cause hematoma formation in the loose retroperitoneal space [46]. Smaller hematoma are subclinical, not recognized and self-limiting. In case of a large hematoma, urgent surgical evacuation is required [94,95].

2) Ecchymosis

Uncontrolled bleeding may lead to seepage of blood under the subcutaneous tissue, leading to ecchymosis around the incisional area. This is a rare occurrence (incidence reported to be 0.76%), and is usually inconsequential, not associated with increased pain, and therefore, no further treatment is required [17].

3) Lumbar segmental artery pseudoaneurysm

The blind-puncture technique in PTELD puts the retroperitoneal structures at risk of injury. In addition to a retroperitoneal hematoma, inadvertent injury to the lumbar segmental artery may manifest in the postoperative period with flank/inguinal region pain due to pseudoaneurysm [96]. Symptomatic patients often require urgent abdominal computed tomography (CT) scans with CT angiography. Treatment can vary from endovascular coiling to vascular repair.

4) Superficial wound infections

Superficial infections are rare in PTELD due to smaller incision and continuous irrigation of the surgical field. However, they can occur with skin incisional margin necrosis especially if there is overzealous under sizing than a 7- to 8-mm incision. Prolonged operative time, especially in cases of stenosis, calcified or central disc herniations can also precipitate wound infection [71]. More invasive endoscopic approach, especially a trans-iliac approach for L5–S1, can lead to concealed muscle injuries, infection and scarring. The routine use of broad-spectrum antibiotics in irrigating fluid should be practiced [97].

2. Execution-Related

1) CSF leak and pseudomeningocele

An unrecognized dural rent may present with persistent postoperative oozing from the wound. Rarely, a pseudomeningocele may form, although the potential space for its formation is limited in the transforaminal approach [98]. Rarely, CSF may leak from the dural puncture area that was repaired or a sealant was applied during the surgery due to straining in the postoperative period. Patients should avoid strenuous activity in the postoperative period, especially when a dural tear has occurred.

3. Natural History/Biology-Related

1) Systemic complications

Systemic complications are rare in TELD. However, sporadic cases of deep vein thrombosis and pulmonary embolism have been reported in the literature [19]. Pulmonary complications like dyspnea, pulmonary edema and respiratory failure can also occur. Hilbert et al. [99] reported severe dyspnea with severe abdominal pain in a patient after endoscopic discectomy. On CT-guided aspiration and analysis, the fluid proved to be surgical irrigation solution.

4. Anesthesia/Sedation-Related

1) Adverse drug reactions to anesthetic agents/opioids/sedatives

POSTOPERATIVE COMPLICATIONS: LATE POSTOPERATIVE

1. Approach-Related

1) Radiation hazards

Radiation safety is an important issue in TELD. The use of fluoroscopy is especially more during the early phase of the learning curve. This not only poses the surgeon, but also the patients at a risk of various adverse effects of ionizing radiation [100]. Ahn et al. [101] reported an average fluoroscopic time of 2.5 minutes per TELD case in their institute. They suggested that surgeons could safely perform approximately 5000 TELD cases using radiation shielding clothes and 291 TELD cases without shielding clothes per year. This is a pretty big adequate number for any surgeon. Ultrasound (US) guided percutaneous needle placement is emerging as an effective alternative to fluoroscopy [102]. The application of enabling technologies like navigation, robotics and US-MRI fusion are also evolving in the field of endoscopic discectomy [103-105].

2. Execution-Related

1) Discal pseudocyst formation

Discal pseudocyst formation is a rare complication of endoscopic discectomy. It was first reported by Young et al. [106]. A discal pseudocyst differs from the juxta-facet, perineural and ganglion cysts as it communicates with the disc space and develops over a relatively short time following discectomy. It can compress the nerve root, resulting in a recurrence or exacerbation of patient’s pre-existing symptoms [107]. Although morphologically and imaging-wise they appear to be like true discal cysts, they lack a true capsule. Advances in imaging techniques have improved the diagnosis of pseudocysts [108]. A repeat TELD with drainage of the cyst is required in symptomatic patients [109].

3. Natural History/Biology-Related

1) Spondylodiskitis

The not-so-uncommon but one of the most problematic infections is spondylodiscitis, though it is rarer after TELD than with open surgeries. An inadvertent puncture of the intestine during initial needle insertion and redirection correctly will contaminate the disc space, leading to secondary spondylodiscitis [110]. If an intestinal injury is suspected, the needle should be changed. Re-entry should be taken under the cover with broad-spectrum antibiotics. Watch for any abdominal complaints. The typical presentation is severe back pain, toxic systemic features at times combined with leg pain and disability. Elevated erythrocyte sedimentation rate and C-reactive protein appear to be more reliable for diagnosis along with radiological findings, especially in the early postoperative phase [111]. For definitive bacteriological diagnosis, disc biopsy under fluoroscopy is needed. The first-line treatment with appropriate antibiotic therapy with limited ambulation and bracing is needed, along with biopsy for evidence-based practice. Re-endoscopic debridement and wash is getting remarkable response in the hands of endoscopic surgeons and is recommended. There are reports of broad-spectrum antibiotics such as vancomycin 1 g being injected into the disc in concentrated paste form. Antibiotic-instilled saline irrigation is used by many surgeons in the primary TELD as a prophylactic measure. The author personally uses Cefazolin and gentamicin. In case of unresponsiveness, open debridement with interbody fusion may be needed [112].

2) Psoas abscess

An inadvertent puncture of the intestine during needle insertion may also lead to psoas abscess if the intestinal flora gets inoculated in the psoas muscle [113]. Similar strategies as in prevention of spondylodiskitis, including change of the needle and re-entry under the cover with broad-spectrum antibiotics, are to be followed. Treatment is appropriate antibiotic therapy guided by culture and sensitivity reports. Coexisting spondylodiskitis should be ruled out or managed as per protocols [110].

3) Recurrence

Radiographic evidence of reherniation of disc fragments at the same level, after a pain-free interval, despite postoperative documentation of removal of all fragments is recurrence in the true sense. After surgery, a hidden intradiscal herniated fragment may extrude from the same side or the contralateral side at the index level. The cutoff timeline for the symptom-free period has always been a matter of debate, and the literature is divided on this. Some authors have given a cutoff of as early as 2 weeks of symptom-free period before calling it a recurrence [114]. Others have given a cutoff ranging from 3 to 6 months [115,116]. To avoid confusion, an arbitrary time of 6 months could be used to define an early recurrence if it occurs within 6 months, and late recurrence if it occurs after 6 months of the index surgery [117]. Variable data claim lesser, more, or similar recurrence rate to that of traditional open or microlumbar discectomy [118-120]. There are reports of recurrence rates of TELD ranging from 0.8% to 15% in the literature [27,116,121]. Yin et al. [122] have reported the highest data, to date, on the prevalence of recurrence after TELD. In their meta-analysis involving 23,930 patients, they reported a recurrence rate of 3.4%.
Recurrence is predisposed by certain risk factors such as insufficient decompression, greater disc height, early and strenuous postoperative activity, presence of Modic changes, among many others [31,114]. Kim et al. [32] have proposed a scoring system to predict the risk for early recurrence in patients undergoing TELD. To reduce the recurrence rate, complete removal of the herniated mass, including the subannular and extruded parts, is very important. However, it does not mean a radical removal of the entire nucleus pulposus, but only the fragmented disc pieces, as aggressive subtotal discectomy can predispose to iatrogenic instability and lower patient satisfaction [123]. Recurrences are mostly managed by reoperations and usually refractory to conservative therapy. The utility of TELD in operating recurrent herniations have been excellent. This is true not only for recurrences due to previous TELD, but also due to traditional microlumbar discectomy. This is because TELD avoids the previous operative scar tissue of the posterior approach and thus provides a better access to the recurrent disc. This minimizes the chances of dural tear or neurologic injury due to fibrotic adhesions at the previously operated area, which is traditionally feared in revision microlumbar discectomy [28,89,124].

4) Epidural fibrosis/scarring

Although this complication is more often reported in open discectomy, excessive removal of outer layer of the annulus/posterior longitudinal ligament (PLL)/ligamentum flavum may cause epidural fibrosis and scarring in TELD patients as well [125]. A careful dissection, limited removal of PLL and ligamentum flavum and annuloplasty using bipolar RF are some of the methods to minimize soft tissue damage at the operative site, causing less postoperative scarring and epidural fibrosis [126]. In symptomatic patients refractory to conservative management, re-exploration and adhesiolysis could be done. There have been reports of endoscopic lumbar adesiolysis as well, with the use of RF or hyaluronic acid [127,128].

5) Secondary degenerative cascade

Disc degeneration is only an initial event in the cascade of spinal degeneration. TELD does not guarantee a halt in the natural history of progression of this degeneration. Moreover, aggressive removal of nucleus pulposus and other supporting structures such as the PLL, ligamentum flavum and facet contributes to acceleration of the process [66,123]. Higher grades of facetectomy can even precipitate an adjacent segment degeneration and co-existence of osteoporosis adds to the woes [129,130]. However, foraminoplasty has been found play a role in delaying, if not preventing late postoperative foraminal stenosis in some studies [131].
These complications can also be further subclassified as firstly as problem (which did not leave any after effects), secondly as obstacle that left a minor after effect or which could be corrected by a medication, and thirdly as a true complication that left a permanent after effect or needed reintervention.
A major concern or limitation for adaptation of TELD has always been a fear of the learning curve associated with it. There is abundant literature reporting a ‘steep’ learning curve for TELD [132,133]. A learning curve for any procedure is a graphical representation of proficiency in its execution as a function of time. It is the number of repetitions that need to be performed before one master the technique, and thus could either be steep or shallow. A steep learning curve is where one becomes proficient in the technique with a small number of repetitions, in contrast to a shallow learning curve, where one needs many repetitions of the task over a long time period to master it. Therefore, a shallow learning curve may reflect that the procedure is more technically demanding and difficult to master, contrary to the common belief that a steep learning curve is more challenging to overcome [134]. Nevertheless, a steeper learning curve phase and initial longer operation times may increase the incidence of complications for novice surgeons. In addition, by expanding the indications, experienced surgeons can add to unknown unreported complications as well. The strategy for dealing with these types of complications best is preventive, and we should be focused on such strategies considered here. Usually, the surgeons who overcome the learning curve end up mastering this technique and these surgeons and patients themselves start to prefer it over traditional techniques because of the lower morbidity and increased efficacy of the procedure. However, open procedures must be mastered by surgeons and are equally necessary in spinal surgery to overcome problems and complications encountered when performing TELD.
As with any technique in modern medicine, a successful TELD is affected by technique and experience. The surgeon should develop capabilities of autonomously using the endoscope and hand instruments and develop hand-eye coordination with tactile feedback. No assistant or accessory holder for the working channel should be practiced. Fluoroscopy should be used to ensure safety at any step of the procedure and for any manipulation confirmation. The legacy of these procedures is that they cause fewer complications due to lesser operative trauma to the musculo-ligamentous complex and spine stability. Different kinds of problems can arise with some frequency as with any surgical procedure. Surgeons should take adequate technical considerations and increase the understanding of the patient's pathoanatomy to reduce complications. The potential complications associated with TELD should be noted, especially those that are surprising and unexpected and undocumented. This is to give safe guidelines to the future generations. Documentation, rating, and follow-up of complications are necessary to gauge treatment decisions and improve informed consent and patient outcomes. Furthermore, with an ageing population and a worldwide struggle with rising healthcare costs, complications are an important socioeconomic factor. Understanding the frequency, type and consequences of complications are the first steps to take to reduce them. Modified ranking scale, Karnofsky Performance Status, modified McCormick scale, Clavien-Dindo Grading System, etc., are the various grading systems of complication in lumbar spine surgery. Future studies could focus on developing a combination scaling system in TELD to make for a better reporting of the complications.

CONCLUSION

Complications in TELD are expected to occur like any surgical procedure but lower are the incidence and minor with surgeons’ proficiency. Documentation, rating, and follow-up of complications are necessary to gauge treatment decisions and improve informed consent and patient outcomes. Future consensus, multicentric studies focusing on developing a better scaling system for reporting of the complications in TELD is recommended.

NOTES

Conflicts of interest

The authors have nothing to disclose.

Funding/Support

This study received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Figure 1.
PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) flow diagram.
jmisst-2025-02019f1.jpg
Table 1.
Detailed search strings for all 3 databases
Database Search strategy
PubMed ((Percutaneous Transforaminal) AND (Endoscopy OR Endoscopic OR Endoskopic) AND (Discectomy OR Diskectomy) AND (Complication))
Scopus (TITLE-ABS-KEY(transforaminal) AND (TITLE-ABS-KEY(endoscopy) OR TITLE-ABS-KEY(endoscopic) OR TITLE-ABS-KEY(endoskopic)) AND (TITLE-ABS-KEY(discectomy) OR TITLE-ABS-KEY(diskectomy)) AND TITLE-ABS-KEY(complication))
Science Direct Title, abstract or author-specified keywords: ((Transforaminal) AND (Endoscopy OR Endoscopic) AND (Discectomy OR Diskectomy) AND (Complication))
Table 2.
Classification of complications in transforaminal endoscopic lumbar discectomy
Based on timeline Based on relation to technique
Approach-related Execution-related Natural history/biology-related Anesthesia/medicines/sedation related
Intraoperative 1. Pain/anxiety/noncompliance 1. Dural injury Seizures Allergy
2. Vascular injury 2. Neurologic Injury Adverse drug reactions
3. Visceral injury 3. Instrument failure
4. Wrong-level surgery 4. Contrast related
5. Iatrogenic bony instability
6. Failure/missed fragment/incomplete decompression
7. Seizures
8. Long duration surgery
9. Bleeding
Postoperative -
 Immediate 1. Dysesthesia 1. Postoperative pain Seizures 1. Transient paresis
 -Nerve root edema 2. Urinary retention
 -Haematoma 3. Adverse drug reactions
 -Residual disc
 -De novo disc prolapse
 -Segmental instability
 -Herniated rootlets from dural rent
2. Neurologic deficit
3. Extravasation of irrigation fluid
4. Pneumocephalus
 Early 1.Retroperitoneal hematoma (psoas also) Cerebrospinal fluid leak/pseudomeningocele Systemic complications: Adverse drug reactions
2. Ecchymosis -Deep vein thrombosis
3. Lumbar segmental artery pseudoaneurysm -Pulmonary embolism
4. Superficial wound infection -Dyspnea
-Pulmonary edema
-Respiratory failure
 Late Radiation hazards Pseudocyst formation 1. Spondylodiscitis Drug dependence
2. Psoas abscess
3. Recurrence
4. Epidural fibrosis/scarring
5. Secondary degenerative cascade
6. Adjacent segment disease

REFERENCES

1. Kim M, Lee S, Kim HS, Park S, Shim SY, Lim DJ. A comparison of percutaneous endoscopic lumbar discectomy and open lumbar microdiscectomy for lumbar disc herniation in the Korean: a meta-analysis. BioMed Res Int 2018;2018:e9073460.
crossref pmid pmc pdf
2. Koebbe CJ, Maroon JC, Abla A, El-Kadi H, Bost J. Lumbar microdiscectomy: a historical perspective and current technical considerations. Neurosurg Focus 2002;13:E3.
crossref pmid
3. Muthu S, Ramakrishnan E, Chellamuthu G. Is endoscopic discectomy the next gold standard in the management of lumbar disc disease? Systematic review and superiority analysis. Glob Spine J 2021;11:1104–20.
crossref pmid pmc pdf
4. Gibson JNA, Cowie JG, Iprenburg M. Transforaminal endoscopic spinal surgery: the future ‘gold standard’ for discectomy? - A review. Surg J R Coll Surg Edinb Irel 2012;10:290–6.
crossref pmid
5. Krishnan A, Kim HS, Raj A, Dave BR. Expanded indications of full endoscopic spine surgery. J Minim Invasive Spine Surg Tech 2021;6(Suppl 1):S130–56.
crossref pdf
6. Krishnan A, Kohli R, Degulmadi D, Mayi S, Ranjan R, Dave B. Cauda equina syndrome: a review of 15 patients who underwent percutaneous transforaminal endoscopic lumbar discectomy (PTELD) under local anaesthesia. Malays Orthop J 2020;14:101–10.
crossref pmid pmc
7. Degulmadi D, Mayi S, Rai RR, Dave MB, Narvekar M, Killekar R, et al. Transforaminal endoscopic ventral stenosis decompression in calcified lumbar disc herniation: a long term outcome in 79 patients. World Neurosurg 2024;186:e191–205.
crossref pmid
8. Ruetten S, Komp M, Godolias G. An extreme lateral access for the surgery of lumbar disc herniations inside the spinal canal using the full-endoscopic uniportal transforaminal approach-technique and prospective results of 463 patients. Spine (Phila Pa 1976) 2005;30:2570–8.
crossref pmid
9. Datar GP, Shinde A, Bommakanti K. Technical consideration of transforaminal endoscopic spine surgery for central herniation. Indian J Pain 2017;31:86.
crossref
10. Yeung A, Roberts A, Zhu L, Qi L, Zhang J, Lewandrowski KU. Treatment of soft tissue and bony spinal stenosis by a visualized endoscopic transforaminal technique under local anesthesia. Neurospine 2019;16:52–62.
crossref pmid pmc pdf
11. Krishnan A, Kulkarni M, Singh M, Reddy C, Mayi S, Devanand D, et al. Trans-foraminal endoscopic uniportal decompression in degenerative lumbar spondylolisthesis: a technical and case report. Egypt J Neurosurg 2019;34:34.
crossref pdf
12. Ahn Y, Lee SG, Son S, Keum HJ. Transforaminal endoscopic lumbar discectomy versus open lumbar microdiscectomy: a comparative cohort study with a 5-year follow-up. Pain Physician 2019;22:295–304.
crossref pmid
13. Zhu Y, Zhao Y, Fan G, Sun S, Zhou Z, Wang D, et al. Comparison of 3 anesthetic methods for percutaneous transforaminal endoscopic discectomy: a prospective study. Pain Physician 2018;21:E347–53.
crossref pmid
14. Lewandrowski KU, Abraham I, Ramírez León JF, Telfeian AE, Lorio MP, Hellinger S, et al. A proposed personalized spine care protocol (SpineScreen) to treat visualized pain generators: an illustrative study comparing clinical outcomes and postoperative reoperations between targeted endoscopic lumbar decompression surgery, minimally invasive TLIF and open laminectomy. J Pers Med 2022;12:1065.
crossref pmid pmc
15. Compagnone D, Mandelli F, Ponzo M, Langella F, Cecchinato R, Damilano M, et al. Complications in endoscopic spine surgery: a systematic review. Eur Spine J 2024;33:401–8.
crossref pmid pdf
16. Kim HS, Sharma SB, Wu PH, Raorane HD, Adsul NM, Singh R, et al. Complications and limitations of endoscopic spine surgery and percutaneous instrumentation. Indian Spine J 2020;3:78–85.
crossref
17. Lewandrowski KU. Incidence, management, and cost of complications after transforaminal endoscopic decompression surgery for lumbar foraminal and lateral recess stenosis: a value proposition for outpatient ambulatory surgery. Int J Spine Surg 2019;13:53–67.
crossref pmid pmc
18. Zhu B, Jiang Y, Shang L, Yan M, Jun Ma H, Ren DJ, et al. Complications of percutaneous endoscopic lumbar discectomy: experiences and literature review. J Spine 2017;6:1000402.
crossref
19. Sen RD, White-Dzuro G, Ruzevick J, Kim CW, Witt JP, Telfeian AE, et al. Intra- and perioperative complications associated with endoscopic spine surgery: a multi-institutional study. World Neurosurg 2018;120:e1054–60.
crossref pmid
20. Zhou C, Zhang G, Panchal RR, Ren X, Xiang H, Xuexiao M, et al. Unique complications of percutaneous endoscopic lumbar discectomy and percutaneous endoscopic interlaminar discectomy. Pain Physician 2018;21:E105–12.
crossref pmid
21. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol 2009;62:e1–34.
crossref pmid
22. Basil GW, Wang MY. Trends in outpatient minimally invasive spine surgery. J Spine Surg 2019;5(Suppl 1):S108–14.
crossref pmid pmc
23. Wang SF, Hung SF, Tsai TT, Li YD, Chiu PY, Hsieh MK, et al. Better functional outcome and pain relief in the far-lateral-outside-in percutaneous endoscopic transforaminal discectomy. J Pain Res 2021;14:3927–34.
crossref pmid pmc pdf
24. An J, Zhang J, Yu T, Wu J, Nie X, He T, et al. A retrospective comparative study of modified percutaneous endoscopic transforaminal discectomy and open lumbar discectomy for gluteal pain caused by lumbar disc herniation. Front Surg 2022;9:930036.
crossref pmid pmc
25. Tamaki Y, Sakai T, Miyagi R, Nakagawa T, Shimakawa T, Sairyo K, et al. Intradural lumbar disc herniation after percutaneous endoscopic lumbar discectomy: case report. J Neurosurg Spine 2015;23:336–9.
crossref pmid
26. Chiu JC, Clifford TJ, Savitz MH, Yeung AT, Batterjee KA, Destandau J, et al. Multicenter study of percutaneous endoscopic discectomy (lumbar, cervical, thoracic). J Minim Invasive Spinal Tech 2001;1:33–7.

27. Choi KC, Lee JH, Kim JS, Sabal LA, Lee S, Kim H, et al. Unsuccessful percutaneous endoscopic lumbar discectomy: a single-center experience of 10,228 cases. Neurosurgery 2015;76:372–80; discussion 380-1; quiz 381.
crossref pmid
28. Ahn Y. Transforaminal percutaneous endoscopic lumbar discectomy: technical tips to prevent complications. Expert Rev Med Devices 2012;9:361–6.
crossref pmid
29. Ju CI. Technical considerations of the transforaminal approach for lumbar disk herniation. World Neurosurg 2021;145:597–611.
crossref pmid
30. Wang A, Yu Z. Comparison of percutaneous endoscopic lumbar discectomy with minimally invasive transforaminal lumbar interbody fusion as a revision surgery for recurrent lumbar disc herniation after percutaneous endoscopic lumbar discectomy. Ther Clin Risk Manag 2020;16:1185–93.
pmid pmc
31. Park CH, Park ES, Lee SH, Lee KK, Kwon YK, Kang MS, et al. Risk factors for early recurrence after transforaminal endoscopic lumbar disc decompression. Pain Physician 2019;22:E133–8.
crossref pmid
32. Kim HS, You JD, Ju CI. Predictive scoring and risk factors of early recurrence after percutaneous endoscopic lumbar discectomy. BioMed Res Int 2019;2019:6492675.
crossref pmid pmc pdf
33. Krishnan A, Chauhan V, Degulmadi D, Mayi S, Ranjan R, Dave MB, et al. Prodrome to seizure in transforaminal endoscopic surgery: a series of 9 cases. J Minim Invasive Spine Surg Tech 2023;8:105–19.
crossref pdf
34. Clavien PA, Barkun J, de Oliveira ML, Vauthey JN, Dindo D, Schulick RD, et al. The Clavien-Dindo classification of surgical complications: five-year experience. Ann Surg 2009;250:187–96.
crossref pmid
35. Kim DJ, Lee JH, Kim W. Comparison of the major postoperative complications between laparoscopic distal and total gastrectomies for gastric cancer using Clavien-Dindo classification. Surg Endosc 2015;29:3196–204.
crossref pmid pdf
36. Mitropoulos D, Artibani W, Biyani CS, Bjerggaard Jensen J, Rouprêt M, Truss M. Validation of the Clavien-Dindo grading system in urology by the European Association of Urology guidelines ad hoc panel. Eur Urol Focus 2018;4:608–13.
crossref pmid
37. Sinha R, Jalote I, Sinha M, Raje S, Rao G. Surgical complications in 448 gynecological 3D laparoscopic surgeries adopting the Clavien—Dindo classification. Gynecol Surg 2016;13:333–8.
crossref pdf
38. Camino Willhuber G, Elizondo C, Slullitel P. Analysis of postoperative complications in spinal surgery, hospital length of stay, and unplanned readmission: application of Dindo-Clavien classification to spine surgery. Glob Spine J 2019;9:279–86.
crossref pmid pmc pdf
39. Fleischer DE, Van de Mierop F, Eisen GM, al-Kawas FH, Benjamin SB, Lewis JH, et al. A new system for defining endoscopic complications emphasizing the measure of importance. Gastrointest Endosc 1997;45:128–33.
crossref pmid
40. Cho JY, Lee SH, Lee HY. Prevention of development of postoperative dysesthesia in transforaminal percutaneous endoscopic lumbar discectomy for intracanalicular lumbar disc herniation: floating retraction technique. Minim Invasive Neurosurg 2011;54:214–8.
crossref pmid
41. Yeung AT, Tsou PM. Posterolateral endoscopic excision for lumbar disc herniation: surgical technique, outcome, and complications in 307 consecutive cases. Spine (Phila Pa 1976) 2002;27:722–31.
crossref pmid
42. Choi I, Ahn JO, So WS, Lee SJ, Choi IJ, Kim H. Exiting root injury in transforaminal endoscopic discectomy: preoperative image considerations for safety. Eur Spine J 2013;22:2481–7.
crossref pmid pmc pdf
43. Oksar M. Sedation for percutaneous endoscopic lumbar discectomy. Sci World J 2016;2016:8767410.
crossref pmid pmc pdf
44. Han IH, Choi BK, Cho WH, Nam KH. The obturator guiding technique in percutaneous endoscopic lumbar discectomy. J Korean Neurosurg Soc 2012;51:182–6.
crossref pmid pmc
45. Wang Y, Ai P, Zhan G, Shen B. Lumbar artery injury during transforaminal percutaneous endoscopic lumbar discectomy: successful treatment by emergent transcatheter arterial embolization. Ann Vasc Surg 2018;53:267.e11–267.e14.
crossref pmid
46. Ahn Y, Kim JU, Lee BH, Lee SH, Park JD, Hong DH, et al. Postoperative retroperitoneal hematoma following transforaminal percutaneous endoscopic lumbar discectomy. J Neurosurg Spine 2009;10:595–602.
crossref pmid
47. Ahn Y, Oh HK, Kim H, Lee SH, Lee HN. Percutaneous endoscopic lumbar foraminotomy: an advanced surgical technique and clinical outcomes. Neurosurgery 2014;75:124–33.
crossref pmid pmc
48. Lee JU, Park KJ, Kim KH, Choi MK, Lee YH, Kim DH. What is the ideal entry point for transforaminal endoscopic lumbar discectomy. J Korean Neurosurg Soc 2020;63:614–22.
crossref pmid pmc pdf
49. Krishnan A, Barot M, Dave B, Bang P, Devanand D, Patel D, et al. Percutaneous transforaminal endoscopic discectomy and drainage for spondylodiscitis: a technical note and review of literature. J Orthop Allied Sci 2018;6:16.
crossref
50. Stoller ML, Wolf JS Jr. Endoscopic ureteral injuries. In: McAninch JW, editor. Traumatic and reconstructive urology. Philadelphia (PA): WB Saunders; 1996. 199:p. 211.

51. Fan G, Guan X, Zhang H, Wu X, Gu X, Gu G, et al. Significant improvement of puncture accuracy and fluoroscopy reduction in percutaneous transforaminal endoscopic discectomy with novel lumbar location system: preliminary report of prospective hello study. Medicine (Baltimore) 2015;94:e2189.
crossref pmid pmc
52. Ju CI, Kim P, Ha SW, Kim SW, Lee SM. Contraindications and complications of full endoscopic lumbar decompression for lumbar spinal stenosis: a systematic review. World Neurosurg 2022;168:398–410.
crossref pmid
53. Jhawar BS, Mitsis D, Duggal N. Wrong-sided and wrong-level neurosurgery: a national survey. J Neurosurg Spine 2007;7:467–72.
crossref pmid
54. Ahn Y, Lee HY, Lee SH, Lee JH. Dural tears in percutaneous endoscopic lumbar discectomy. Eur Spine J 2011;20:58–64.
crossref pmid pmc pdf
55. Ducati LG, Silva MV, Brandão MM, Romero FR, Zanini MA. Intradural lumbar disc herniation: report of five cases with literature review. Eur Spine J 2013;22 Suppl 3(Suppl 3):S404–8.
crossref pmid pmc pdf
56. Lewandrowski KU, Hellinger S, De Carvalho PST, Freitas Ramos MR, Soriano-Sánchez JA, Xifeng Z, et al. Dural tears during lumbar spinal endoscopy: surgeon skill, training, incidence, risk factors, and management. Int J Spine Surg 2021;15:280–94.
crossref pmid pmc
57. Wang JC, Bohlman HH, Riew KD. Dural tears secondary to operations on the lumbar spine. Management and results after a two-year-minimum follow-up of eighty-eight patients. J Bone Joint Surg Am 1998;80:1728–32.
crossref pmid
58. Ahn Y. Transforaminal endoscopic lumbar discectomy. In: Core Tech of Minim Invasive Spine Surg [Internet]. Springer Nature; 2023. p. 29-38. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85170623903&doi=10.1007%2f978-981-19-9849-2_5&partnerID=40&md5=a03d6d02d465e631c123e8f2489f6e78.

59. Wang Y, Zhang W, Lian L, Xu J, Ding W. Transforaminal endoscopic discectomy for treatment of central disc herniation: surgical techniques and clinical outcome. Pain Physician 2018;21:E113–23.
crossref pmid
60. Song SJ, Lee JW, Choi JY, Hong SH, Kim NR, Kim KJ, et al. Imaging features suggestive of a conjoined nerve root on routine axial MRI. Skeletal Radiol 2008;37:133–8.
crossref pmid pdf
61. Domsky R, Goldberg ME, Hirsh RA, Scaringe D, Torjman MC. Critical failure of a percutaneous discectomy probe requiring surgical removal during disc decompression. Reg Anesth Pain Med 2006;31:177–9.
crossref pmid
62. Mortelé KJ, Oliva MR, Ondategui S, Ros PR, Silverman SG. Universal use of nonionic iodinated contrast medium for CT: evaluation of safety in a large urban teaching hospital. AJR Am J Roentgenol 2005;184:31–4.
crossref pmid
63. Morzycki A, Bhatia A, Murphy KJ. Adverse reactions to contrast material: a canadian update. Can Assoc Radiol J 2017;68:187–93.
crossref pmid pdf
64. Boswell MV, Wolfe JR. Intrathecal cefazolin-induced seizures following attempted discography. Pain Physician 2004;7:103–6.
crossref pmid
65. Kazbek BK, Yılmaz H, Kazancı B, Ekmekçi P, Sabuncuoğlu H. Severe hypertension and tachycardia during transforaminal endoscopic discectomy - is indigocarmine to blame. Neurocirugia 2019;30:50–2.
crossref pmid
66. Qiao P, Xu T, Zhang W, Fang Z, Ding W, Tian R. Foraminoplasty affects the clinical outcomes of discectomy during percutaneous transforaminal endoscopy: a two-year follow-up retrospective study on 64 patients. Int J Neurosci 2021;131:1–6.
crossref pmid
67. Tezuka F, Sakai T, Abe M, Yamashita K, Takata Y, Higashino K, et al. Anatomical considerations of the iliac crest on percutaneous endoscopic discectomy using a transforaminal approach. Spine J 2017;17:1875–80.
crossref pmid
68. Huang JS, Fan BK, Liu JM. [Overview of risk factors for failed percutaneous transforaminal endoscopic discectomy in lumbar disc herniation]. Zhongguo Gu Shang China J Orthop Traumatol 2019;32:186–9.

69. Son S, Ahn Y, Lee SG, Kim WK, Yoo BR, Jung JM, et al. Learning curve of percutaneous endoscopic transforaminal lumbar discectomy by a single surgeon. Medicine (Baltimore) 2021;100:e24346.
crossref pmid pmc
70. Choi G, Modi HN, Prada N, Ahn TJ, Myung SH, Gang MS, et al. Clinical results of XMR-assisted percutaneous transforaminal endoscopic lumbar discectomy. J Orthop Surg 2013;8:14.
crossref pmid pmc pdf
71. Lewandrowski KU. Readmissions after outpatient transforaminal decompression for lumbar foraminal and lateral recess stenosis. Int J Spine Surg 2018;12:342–51.
crossref pmid pmc
72. Zhang Y, Zhu H, Zhou Z, Wu J, Sun Y, Shen X, et al. Comparison between percutaneous transforaminal endoscopic discectomy and fenestration in the treatment of degenerative lumbar spinal stenosis. Med Sci Monit Int Med J Exp Clin Res 2020;26:e926631.
crossref pmid pmc
73. Krishnan A, Patel JG, Patel D, Patel PR. Fracture of posterior margin of lumbar vertebral body. Indian J Orthop 2005;39:33–8.

74. Rajasekaran S, Bajaj N, Tubaki V, Kanna RM, Shetty AP. ISSLS Prize winner: the anatomy of failure in lumbar disc herniation: an in vivo, multimodal, prospective study of 181 subjects. Spine (Phila Pa 1976) 2013;38:1491–500.
crossref pmid
75. Krishnan A, Marathe N, Degulmadi D, Mayi S, Ranjan R, Bali SK, et al. End-points of decompression of in lumbar transforaminal endoscopic spine surgery: a narrative review of objective and subjective criteria to prevent failures. J Minim Invasive Spine Surg Tech 2022;7:68–83.
crossref pdf
76. Kertmen H, Gürer B, Yilmaz ER, Sekerci Z. Postoperative seizure following transforaminal percutaneous endoscopic lumbar discectomy. Asian J Neurosurg 2016;11:450.
crossref pmid pmc
77. Choi G, Kang HY, Modi HN, Prada N, Nicolau RJ, Joh JY, et al. Risk of developing seizure after percutaneous endoscopic lumbar discectomy. J Spinal Disord Tech 2011;24:83–92.
crossref pmid
78. Bajaj AI, Yap N, Derman PB, Konakondla S, Kashlan ON, Telfeian AE, et al. Comparative analysis of perioperative characteristics and early outcomes in transforaminal endoscopic lumbar diskectomy: general anesthesia versus conscious sedation. Eur Spine J 2023;32:2896–902.
crossref pmid pdf
79. Kang SY, Cho HS, Yi J, Kim HS, Jang IT, Kim DH. The comparison of fluoroscopy-guided epidural anesthesia with conscious sedation and general anesthesia for endoscopic lumbar decompression surgery: a retrospective analysis. World Neurosurg 2022;159:e103–12.
crossref pmid
80. Fan Y, Gu G, Fan G, Zhu Y, Yang Y, Gu X, et al. The effect of preoperative administration of morphine in alleviating intraoperative pain of percutaneous transforaminal endoscopic discectomy under local anesthesia: a STROBE compliant study. Medicine (Baltimore) 2017;96:e8427.
crossref pmid pmc
81. Lee M, Silverman SM, Hansen H, Patel VB, Manchikanti L. A comprehensive review of opioid-induced hyperalgesia. Pain Physician 2011;14:145–61.
crossref pmid
82. Abrão J, Dowling Á, León JFR, Lewandrowski KU. Anesthesia for endoscopic spine surgery of the spine in an ambulatory surgery center. Glob J Anesth Pain Med 2020;3:326–36.
crossref
83. Fang G, Ding Z, Song Z. Comparison of the effects of epidural anesthesia and local anesthesia in lumbar transforaminal endoscopic surgery. Pain Physician 2016;19:E1001–4.
crossref pmid
84. Wu Z, He J, Cheng H, Lin S, Zhang P, Liang D, et al. Clinical efficacy of general anesthesia versus local anesthesia for percutaneous transforaminal endoscopic discectomy. Front Surg 2022;9:1076257.
crossref pmid pmc
85. Ahn Y, Lee SH, Lee JH, Kim JU, Liu WC. Transforaminal percutaneous endoscopic lumbar discectomy for upper lumbar disc herniation: clinical outcome, prognostic factors, and technical consideration. Acta Neurochir (Wien) 2009;151:199–206.
crossref pmid pdf
86. Lewandrowski KU, Dowling Á, Calderaro AL, Dos Santos TS, Bergamaschi JPM, León JFR, et al. Dysethesia due to irritation of the dorsal root ganglion following lumbar transforaminal endoscopy: Analysis of frequency and contributing factors. Clin Neurol Neurosurg 2020;197:106073.
crossref pmid
87. de Carvalho PST, Ramos MRF, da Silva Meireles AC, Peixoto A, de Carvalho P, Ramírez León JF, et al. Feasibility of using intraoperative neuromonitoring in the prophylaxis of dysesthesia in transforaminal endoscopic discectomies of the lumbar spine. Brain Sci 2020;10:522.
crossref pmid pmc
88. Choi KC, Shim HK, Lee DC, Park CK. Intraoperative disc prolapse during percutaneous endoscopic lumbar discectomy. World Neurosurg 2019;123:81–5.
crossref pmid
89. Ahn Y, Lee SH, Park WM, Lee HY, Shin SW, Kang HY. Percutaneous endoscopic lumbar discectomy for recurrent disc herniation: surgical technique, outcome, and prognostic factors of 43 consecutive cases. Spine (Phila Pa 1976) 2004;29:E326–32.
crossref pmid
90. Sairyo K, Matsuura T, Higashino K, Sakai T, Takata Y, Goda Y, et al. Surgery related complications in percutaneous endoscopic lumbar discectomy under local anesthesia. J Med Investig 2014;61:264–9.
crossref pmid
91. Karavelioglu E, Eser O, Haktanir A. Pneumocephalus and pneumorrhachis after spinal surgery: case report and review of the literature. Neurol Med Chir (Tokyo) 2014;54:405–7.
crossref pmid pmc
92. Lin CH, Lin SM, Lan TY, Pao JL. Pneumocephalus with conscious disturbance after full endoscopic lumbar diskectomy. World Neurosurg 2019;131:112–5.
crossref pmid
93. Zhu Y, Zhao Y, Fan G, Gu G, Sun S, Hu S, et al. Comparison of the effects of local anesthesia and epidural anesthesia for percutaneous transforaminal endoscopic discectomy in elderly patients over 65 years old. Int J Surg Lond Engl 2017;48:260–3.
crossref pmid
94. Wang H, Zhou F, Wen B, Liang G, Wu J. Retroperitoneal hematoma following transforaminal percutaneous endoscopic lumbar discectomy: 3 cases reports and literature review. Chin J Anat Clin 2019;24:65–70.

95. Bae DH, Eun SS, Lee SH, Lee SM. Two cases of retroperitoneal hematoma after transforaminal percutaneous endoscopic lumbar discectomy. Interdiscip Neurosurg 2020;20:100649.
crossref
96. Panagiotopoulos K, Gazzeri R, Bruni A, Agrillo U. Pseudoaneurysm of a segmental lumbar artery following a full-endoscopic transforaminal lumbar discectomy: a rare approach-related complication. Acta Neurochir (Wien) 2019;161:907–10.
crossref pmid pdf
97. Yeung AT. The evolution and advancement of endoscopic foraminal surgery: one surgeon’s experience incorporating adjunctive technologies. SAS J 2007;1:108–17.
pmid pmc
98. Telfeian AE, Shen J, Ali R, Oyelese A, Fridley J, Gokaslan ZL. Incidence and implications of incidental durotomy in transforaminal endoscopic spine surgery: case series. World Neurosurg 2020;134:e951–5.
crossref pmid
99. Hilbert T, Boehm O, Pflugmacher R, Wirtz DC, Baumgarten G, Knuefermann P. [Rare complication after endoscopic discectomy]. Anaesthesist 2014;63:41–6.
crossref pmid pdf
100. Srinivasan D, Than KD, Wang AC, La Marca F, Wang PI, Schermerhorn TC, et al. Radiation safety and spine surgery: systematic review of exposure limits and methods to minimize radiation exposure. World Neurosurg 2014;82:1337–43.
crossref pmid
101. Ahn Y, Kim CH, Lee JH, Lee SH, Kim JS. Radiation exposure to the surgeon during percutaneous endoscopic lumbar discectomy: a prospective study. Spine (Phila Pa 1976) 2013;38:617–25.
crossref pmid
102. Wu RH, Deng DH, Huang XQ, Shi CL, Liao XQ. Radiation exposure reduction in ultrasound-guided transforaminal percutaneous endoscopic lumbar discectomy for lumbar disc herniation: a randomized controlled trial. World Neurosurg 2019;124:e633–40.
crossref pmid
103. Han W, Yajun L, Mingxing F, Zhan S, Jintao A, Wei T, et al. Clinical outcomes of robot-assisted transforaminal percutaneous endoscopic lumbar discectomy. Chin J Orthop 2022;42:84–92.

104. Xie P, Feng F, Cao J, Chen Z, He B, Kang Z, et al. Real-time ultrasonography-magnetic resonance image fusion navigation for percutaneous transforaminal endoscopic discectomy. J Neurosurg Spine 2020;33:192–8.
crossref pmid
105. Zhao Y, Bo X, Wang C, Hu S, Zhang T, Lin P, et al. Guided punctures with ultrasound volume navigation in percutaneous transforaminal endoscopic discectomy: a technical note. World Neurosurg 2018;119:77–84.
crossref pmid
106. Young PM, Fenton DS, Czervionke LF. Postoperative annular pseudocyst: report of two cases with an unusual complication after microdiscectomy, and successful treatment by percutaneous aspiration and steroid injection. Spine J 2009;9:e9–15.
crossref pmid
107. Kang SH, Park SW. Symptomatic post-discectomy pseudocyst after endoscopic lumbar discectomy. J Korean Neurosurg Soc 2011;49:31–6.
crossref pmid pmc
108. Cao Z, Cong Y, Yin C, Wang Y, Wang Z, Liu X, et al. A review and summary of patients with symptomatic postoperative discal pseudocysts of the lumbar spine. Orthop Surg 2023;15:1256–63.
crossref pmid pmc
109. Wang S, Yang Y, Yu X, Chang Z. Postoperative discal pseudocyst after percutaneous endoscopic transforaminal discectomy treated by drainage: case report. Medicine (Baltimore) 2022;101:e30204.
crossref pmid pmc
110. Choi KB, Lee CD, Lee SH. Pyogenic spondylodiscitis after percutaneous endoscopic lumbar discectomy. J Korean Neurosurg Soc 2010;48:455–60.
crossref pmid pmc
111. Ahn Y, Lee SH. Postoperative spondylodiscitis following transforaminal percutaneous endoscopic lumbar discectomy: clinical characteristics and preventive strategies. Br J Neurosurg 2012;26:482–6.
crossref pmid
112. Krishnan A, Chauhan V, Degulmadi D, Mayi S, Rai RR, Dave M, et al. Postoperative lumbar spondylodiscitis following transforaminal endoscopy and outcomes of transforaminal lumbar interbody fusion. J Minim Invasive Spine Surg Tech 2023;8:S39–50.
crossref pdf
113. Kim W. Pyogenic psoas abscess and secondary spondylodiscitis as a rare complication of percutaneous endoscopic lumbar discectomy: a case report. Jt Dis Relat Surg 2005;16:163–6.

114. Kim JM, Lee SH, Ahn Y, Yoon DH, Lee CD, Lim ST. Recurrence after successful percutaneous endoscopic lumbar discectomy. Minim Invasive Neurosurg MIN 2007;50:82–5.
crossref pmid
115. Hoogland T, Van Den Brekel-Dijkstra K, Schubert M, Miklitz B. Endoscopic transforaminal discectomy for recurrent lumbar disc herniation: a prospective, cohort evaluation of 262 consecutive cases. Spine 2008;33:973–8.
crossref pmid
116. Swartz KR, Trost GR. Recurrent lumbar disc herniation. Neurosurg Focus 2003;15:E10.
crossref pmid
117. Cheng J, Wang H, Zheng W, Li C, Wang J, Zhang Z, et al. Reoperation after lumbar disc surgery in two hundred and seven patients. Int Orthop 2013;37:1511–7.
crossref pmid pmc pdf
118. Ruetten S, Komp M, Merk H, Godolias G. Full-endoscopic interlaminar and transforaminal lumbar discectomy versus conventional microsurgical technique: a prospective, randomized, controlled study. Spine (Phila Pa 1976) 2008;33:931–9.
crossref pmid
119. Ahn SS, Kim SH, Kim DW, Lee BH. Comparison of outcomes of percutaneous endoscopic lumbar discectomy and open lumbar microdiscectomy for young adults: a retrospective matched cohort study. World Neurosurg 2016;86:250–8.
crossref pmid
120. Zhang B, Liu S, Liu J, Yu B, Guo W, Li Y, et al. Transforaminal endoscopic discectomy versus conventional microdiscectomy for lumbar discherniation: a systematic review and meta-analysis. J Orthop Surg Res 2018;13:169.
crossref pmid pmc pdf
121. Kim MJ, Lee SH, Jung ES, Son BG, Choi ES, Shin JH, et al. Targeted percutaneous transforaminal endoscopic diskectomy in 295 patients: comparison with results of microscopic diskectomy. Surg Neurol 2007;68:623–31.
crossref pmid
122. Yin S, Du H, Yang W, Duan C, Feng C, Tao H. Prevalence of recurrent herniation following percutaneous endoscopic lumbar discectomy: a meta-analysis. Pain Physician 2018;21:337–50.
crossref pmid
123. Carragee EJ, Spinnickie AO, Alamin TF, Paragioudakis S. A prospective controlled study of limited versus subtotal posterior discectomy: short-term outcomes in patients with herniated lumbar intervertebral discs and large posterior anular defect. Spine (Phila Pa 1976) 2006;31:653–7.
crossref pmid
124. Lee DY, Shim CS, Ahn Y, Choi YG, Kim HJ, Lee SH. Comparison of percutaneous endoscopic lumbar discectomy and open lumbar microdiscectomy for recurrent disc herniation. J Korean Neurosurg Soc 2009;46:515–21.
crossref pmid pmc
125. Ferdinandov D. Feasibility and surgical technique of percutaneous transforaminal discectomy for the treatment of lumbar disc herniation. Rheumatol Bulg 2021;29:85–94.
crossref pdf
126. Cheng J, Zheng W, Wang H, Li C, Wang J, Zhang Z, et al. Posterolateral transforaminal selective endoscopic diskectomy with thermal annuloplasty for discogenic low back pain: a prospective observational study. Spine 2014;39(26B):B60–5.
crossref pmid
127. Lee HJ, Kim JS, Ryu KS. Transforaminal percutaneous endoscopic lumbar diskectomy with percutaneous epidural neuroplasty in lumbar disk herniation: technical note. World Neurosurg 2017;98:876.e23–876.e31.
crossref pmid
128. Pereira P, Severo M, Monteiro P, Silva PA, Rebelo V, Castro-Lopes JM, et al. Results of lumbar endoscopic adhesiolysis using a radiofrequency catheter in patients with postoperative fibrosis and persistent or recurrent symptoms after discectomy. Pain Pract 2016;16:67–79.
crossref pmid
129. Li J, Li H, He Y, Zhang X, Xi Z, Wang G, et al. The protection of superior articular process in percutaneous transforaminal endoscopic discectomy should decreases the risk of adjacent segment diseases biomechanically. J Clin Neurosci 2020;79:54–9.
crossref pmid
130. Li J, Xu W, Zhang X, Xi Z, Xie L. Biomechanical role of osteoporosis affects the incidence of adjacent segment disease after percutaneous transforaminal endoscopic discectomy. J Orthop Surg Res 2019;14:131.
crossref pmid pmc pdf
131. Li J, Xu C, Zhang X, Xi Z, Liu M, Fang Z, et al. TELD with limited foraminoplasty has potential biomechanical advantages over TELD with large annuloplasty: an in-silico study. BMC Musculoskelet Disord 2021;22:616.
crossref pmid pmc pdf
132. Hsu HT, Chang SJ, Yang SS, Chai CL. Learning curve of full-endoscopic lumbar discectomy. Eur Spine J 2013;22:727–33.
crossref pmid pmc pdf
133. Tenenbaum S, Arzi H, Herman A, Friedlander A, Levinkopf M, Arnold PM, et al. Percutaneous posterolateral transforaminal endoscopic discectomy: clinical outcome, complications, and learning curve evaluation. Surg Technol Int 2011;21:278–83.
pmid
134. Benzel EC, Orr RD. A steep learning curve is a good thing! Spine J 2011;11:131–2.
crossref pmid
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