Effect of Indirect Neural Decompression by Minimally Invasive Oblique Lumbar Interbody Fusion in Adult Degenerative Lumbar Spine Disease and Its Limitations
Article information
Abstract
Objective
To study efficacy of minimally invasive oblique lumbar interbody fusion (MIS OLIF) to achieve indirect decompression in degenerative lumbar spine disorders. To find out amount of indirect decompression achieved by assessing clinical and radiological outcomes. To find out limitations of indirect decompression.
Methods
OLIF was carried out in 60 segments/45 patients having degenerative lumbar spine disorders from May 2016 to April 2018. Patients with infection, trauma, lumbar disc prolapse and listhesis >grade 3 were excluded. 53 segments had posterior and 7 segments had anterior fixation. Auto graft was used in 21 and artificial bone graft in 24 patients. Indirect decompression by MIS OLIF was achieved in all patients. Neuromonitioring was not used. Clinical assessment was done using Modified Macnab’s criteria. Radiological assessment was done on X-rays and MRI. Percentage improvement in foraminal height, disc height, segmental lordosis, spinal canal area and reduction in listhesis were measured. Statistical assessment was done using Paired‘t’ test.
Results
60 segments of 45 consecutive patients were operated with 15 of them male and 30 female. Average age was 63 years. Minimum follow-up was for 1 month and maximum follow-up was for 18 months with average of 11 months. Single segment fusion was done in 31, 2 segment fusion in 13 and 3 segment fusion in 1 patient. Clinically 33 (73.33%) had excellent, 11 (24.44%) had good & 1 (2.22%) had fair outcomes. None required direct decompression. Radiologically; foraminal height improved by 26.27%, disc height 92.1%, segmental lordosis 3.4° and listhesis reduction was 6.8°, 41 segments studied on MRI had improvement in spinal canal area of 42.7%.
Conclusion
Indirect decompression by MIS OLIF is effective in decompressing the spinal canal with good radiological and clinical out comes. Direct decompression is avoidable with help of interbody distraction using OLIF particularly in patients with Schizas grade A, B, and C of lumbar spinal stenosis.
INTRODUCTION
Lumbar spinal stenosis as a result of the hypertrophy of the articular process was first described by Verbiest in 1954 [1].It has two components viz. Static and dynamic. It is known that the changes in acquired lumbar spinal stenosis are because of the soft tissue as well as bony components of the spinal canal. The cascade which affects the facet joints as well as disc and other soft tissues are well depicted by Kilkardy Willis [2]. Due to ageing process and repetitive loading and unloading of the spine there is disc degeneration and facet joint osteoarthritis which is a pathoanatomical feature associated with sagittal orientation of facets and degenerative spondylolysthesis [3,4]. These changes will make spine more unstable and increase mechanical stresses on the ligamentum flavum which causes its hypertrophy [5,6]. All these changes ultimately lead to narrowing of the canal and encroachment on its contents. The patients in the unstable phase of this cascade will clinically present with neurogenic claudication without rest pain. Symptomatic patients with unstable spine will require stabilization along with decompression. As a conventional mode of treatment they are treated with direct decompression along with stabilization. However with the recent views, these subset of patients can be treated with indirect decompression through restoration of the disc height and foraminal height by ligamentotaxis effect of distraction of the disc space. This can help us avoid all the complications which are related with conventional posterior direct decompression and interbody fusion including more muscle damage, bony resection of lamina and facets, bleeding, nerve root injuries, dural tear, epidural bleeding, hematoma, deep wound infection, perineural fibrosis etc. Various studies have described efficacy of anterior approach like ALIF and lateral approaches like XLIF/LLIF and OLIF to decompress the neural elements indirectly [7-17]. Transpsoas approach (LLIF/XLIF) is associated with higher rates of approach related neurological complications due to injury to lumbar complex. There is reported neurological complication rate of 3-33% in literature [18]. ALIF is possible only at L5-S1 level where as OLIF can be done at all lumbar segments. Also, ALIF is done through open retroperitoneal approach which has higher approach related morbidities as compared to OLIF which can be done through minimal access approach.
Minimally Invasive OLIF has several advantages like less blood loss, shorter hospital stay, less back pain and faster recovery; all in comparison to posterior direct approaches. It is a retroperitoneal approach which uses an oblique corridor between great vessels anteriorly and psoas posteriorly; first described by Michael Mayer in 1997 [19,20]. It retains all the advantages of anterior approaches viz. restoration of disc height, opening up of the foramen and restoration of segmental lordosis with the help of ligamentotaxis, keeping ALL and PLL intact which are major stabilizing structures of spine [21,22]. As it is an anterior to psoas approach it avoids complications occurring because of lumbar plexus injuries like paresthesia of anterior thigh, psoas weakness etc [23,24]. Hence, OLIF can be done without neuromonitoring as well.
This study focuses on efficacy of minimal invasive (OLIF) to stabilize the spine and to achieve indirect neural decompression in degenerative lumbar spine disorders. However it has not been clearly understood in which cases we can avoid direct decompression. In this study we have quantified the amount of indirect decompression OLIF can achieve and in which cases it is feasible to use them by assessing clinical and preoperative and postoperative radiological parameters like changes in disc height, foramen height, spinal canal area as well as restoration of segmental lordosis.
Aim of the Study
* To assess efficacy of OLIF to achieve indirect decompression in degenerative lumbar spine disorders.
* Quantify the amount of indirect decompression achieved by assessing clinical outcomes and radiological parameters.
* Limitations of indirect decompression.
* To assess the patients who required direct decompression after performing OLIF.
MATERIALS AND METHOD
Retrospective analysis of 45 consecutive patients was done from May 2016 to April 2018 in whom minimally invasive oblique lumbar interbody fusion was carried out. These patients had in total 60 segments operated.
Inclusion criteria were failed conservative line of management for low back pain with or without radicular pain and neurogenic claudication in lower limbs which got relieved with rest. Exclusion criteria were rest pain, infection, trauma, spondylolisthesis more than grade 3 and acute lumbar disc prolapse. All included patients were counselled for the requirement of direct decompression in case of persistent symptoms after OLIF.
Clinical and neurological assessment of all the patients was done. Radiological analysis was done using standardized plain AP and Lateral dynamic X-rays and MRI of lumbosacral spine. Appropriate size of cage was inserted using retroperitoneal oblique corridor under IITV guidance. Bone graft was also used along with cage. Autograft was used in 21 patients and artificial bone graft with bone marrow aspirate was used in 24 patients. After cage insertion, fixation of the lumbar segment was done in the same stage. Posterior percutaneous fixation was done in 53 whereas anterior fixation was done in 7 segments. No direct decompression was done. No Neuromonitoring was carried out. Perioperative complications were noted and follow-up was done at 1, 3, and 6 months and at 1 year. Postoperative clinical assessment was done using Modified Macnab’s criteria.
Postoperative X-rays of lumbosacral spine AP and lateral view were taken in all patients. X-rays were taken at 1 month, 3 months, 6 months and 1 year follow-up. Immediate postoperative MRI was studied in 41 segments. All these segments were divided into two groups depending on Schizas grading [25] of lumbar spinal stenosis. Group 1 had class A+B patients whereas group 2 had class C+D patients. Group 1 had 25 segments of 21 patients and group 2 had 16 segments of 16 patients. Figure 1 enumerates the Schizas classification of lumbar spinal stenosis. In grade A stenosis: there is clearly CSF visible inside the dural sac, but its distribution is inhomogeneous. Grade B stenosis: the rootlets occupy the whole of the dural sac, but they can still be individualized. Some CSF is still present giving a grainy appearance to the sac. Grade C stenosis: no rootlets can be recognized, the dural sac demonstrates homogeneous gray signal with no CSF signal is visible. There is epidural fat present posteriorly. Grade D stenosis: in addition to no rootlets being recognizable there is no epidural fat posteriorly.
Schizas Grading. Ⓐ Schizas grade A. Ⓑ Schizas grade B. Ⓒ Schizas grade C. Ⓓ Schizas grade D.
Assessment of radiological parameters: Percentage improvement in disc height, foraminal height, segmental lordosis on X-rays, reduction of slippage of vertebrae and increase in overall area of spinal canal area were noted to assess indirect decompression. All results were statistically analyzed using ‘paired T’ test. Surgimap was used for calculation of parameters. To calculate the disc height a perpendicular line was drawn from the midpoint of cranial vertebra of the respective disc space to the caudal endplate and this length was taken as disc height. Segmental lordosis was measured as the sagittal Cobb’s angle of the cranial and caudal endplate of the involved disc. Foraminal height was also measured between cranial most and caudal most point of the foramen on true lateral X-ray lumbosacral spine. Spinal canal area was measured on MRI on single axial slice through the center of the disc. Outlines of the spinal canal area were mapped manually on the software and the area enclosed was measured (Fig. 2). Pre-op and post-op comparisons of all these parameters were done and percentage improvement was calculated. Measurements were taken by two surgeons and average of it was taken as the final measurement.
Ⓐ Technique to measure radiological parameters on X-ray, Ⓑ Technique to measure spinal canal area on MRI.
1. OLIF Procedure
* The patient was positioned in a true right lateral decubitus position. A 4- to 5-cm skin incision 3-4 cm anterior to the desired disc space after marking under IITV, parallel to the fibers of the external oblique muscle, was put. The approach was usually performed from the left side but could also be performed from the right side, especially in patients who had previously received the procedure from the left side.
* The external oblique, internal oblique and transverse abdominal muscles were then dissected along the direction of their fibers.
* The retroperitoneal space was accessed by blunt dissection, and the peritoneal content was mobilized anteriorly. The psoas muscle and genitofemoral nerve were identified, and the intervertebral disc was exposed through an open corridor between the psoas muscle posteriorly and great vessels anteriorly.
* First dilator was placed over the disc space at junction of anterior 1/3rd and posterior 2/3rd, which was identified fluoroscopically. A guide wire was then introduced through the first dilator into the disc space. The first dilator was then hammered inside the disc space and the guide wire was removed. Sequential dilators were placed over the first dilator. Expandable tubular retractor of appropriate size was placed over the final dilator and docked on to the disc space.
* A distractor pin was used which also served to retain the tubular retractor in place over the disc space.
* Annulotomy was done over the disc and, the disc material including the cartilaginous endplate was excised sequentially by rongeurs, shavers and curettes. The annulus fibrosis at the opposite side was released completely with caution using Cobb elevator under fluoroscopic viewing. Orthogonal maneuver was used for all the instruments for disc preparation inside the disc space. The psoas muscle was retracted temporally during the maneuver.
* Cage size was determined by appropriate sizers, which were
inserted into disc space and confirmed on IITV images.
* An appropriate-sized cage was filled with autologous bone graft from the iliac crest or synthetic bone substitute and was inserted in a press-fit fashion into the disc space. Because these maneuvers are performed anterior to psoas muscle and the retraction was gentle and temporary, neuromonitoring was not needed. Upon insertion of cage either anterior fixation was done or the patient was turned to the prone position, and supplemental percutaneous posterior pedicle screws were placed. Compression was done.
RESULTS
1. Demographic Characteristics
60 segments of 45 consecutive patients (15 males and 30 females) were operated. Average age was 63 years. Minimum follow-up was for 1 month and maximum follow-up was for 18 months with average of 11 months. Thirty one patients had degenerative listhesis, 2 had disc degeneration, 3 had lytic listhesis, 4 had lumbar canal stenosis without instability noted on dynamic X-rays and 5 had adjacent segment disease. Single segment fusion was done in 31 patients, double level fusion done in 13 patients whereas 3 segment fusion done in 1 patient. Average estimated duration for single segment cage placement was 40 minutes (Table 1).
Demographic characteristics
Complications: There were some approach related complications. Major per-operative complication was rupture of the iliolumbar vein in 1 (2.22%) patient. However it was effectively controlled with help of hemocoagulants and without any post-op morbidity. Other per-op complications included peritoneumbreach in 2 (4.44%) patients which was sutured and fracture of the superior endplate or inferior endplates in 2 (4.44%) patients during cage preparation who were severely osteoporotic. Per-op complication rate was 11%.
Post operative complications were: One patient (2.44%) had superficial and 1 patient (2.44%) had deep infection which got resolved with oral antibiotics. Two patients (4.44%) had numbness in area distribution of genitofemoral nerve. Other notable complication was contralateral radiculopathy which was present in 7 (15.55%) patients. Overall rate of postoperative complication was 33%. Noteworthy is the fact that most of these complications were reversible. Autograft was taken in 21 patients. Amongst them 11 (24.44%) had hip flexion weakness due to pain. However all of them recovered within 2-8 weeks with average recovery of 6 weeks. Three (6.67%) patients had fracture of the anterior iliac spine which got healed with rest. None had ureteric or permanent neurologic deficit. None of the patients required direct decompression.
Clinical Results: Clinical assessment was done according to Modified Macnab’s criteria. Thirty three (73.33%) patients had excellent result, 11 (24.44%) had good result and 1 (2.22%) had fair result (Table 2, Chart 1). Overall 98% patients had excellent to good clinical outcome.
Clinical results
Macnab's criteria.
Average hospital stay of the patients was 2 days. On an average, the patients resumed their normal activities within 3 weeks of surgery.
Radiological Results:
The following parameters were studied either on X-rays or MRI:
* foraminal height
* disc height
* reduction in vertebra slippage (listhesis)
* Improvement in segmental lordosis
* Spinal canal area
Total 41 segments were studied on MRI. The rest of the segments could not be studied well because of the artifact effect. Comparison of pre-operative and post-operative data was done and mean of percentage improvement was calculated (Table 3).
Radiological outcomes
All the segments were divided into two groups, depending upon Schizas MRI grading of lumbar canal stenosis, and improvement in spinal canal area was compared between two groups.
Improvement in foraminal height was 26.27% and has been shown in Figure 3 and Chart 2.
Ⓐ, Ⓑ Increase in foraminal height at L2-3, L3-4, L4-5 levels after OLIF.
Foraminal height.
Improvement in disc height was 92.1% and has been shown in Figure 4 and Chart 3.
Ⓐ, Ⓑ Restoration of Disc height at L3-4 and L4-5 is remarkable after OLIF.
Disc height.
Improvement in listhesis reduction was 6.8° and has been shown in Figure 5 and Chart 4.
Ⓐ, Ⓑ Reduction in slippage(lystheis) at L4-5 after OLIF.
Listhesis reduction.
Improvement in segmental lordosis was 3.4° and has been shown in Figure 6 and Chart 5. It was noted that if the cage position were more anterior, it would achieve more segmental lordosis whereas middle or posterior position would have lesser improvement in segmental lordosis.
Ⓐ, Ⓑ Restoration of the segmental lordosis at operated levels. Cage position can influence lordosis achieved.
Improvement in segmental lordosis.
Improvement in spinal canal area was 42.7% overall and has been shown in Figure 7 and Chart 6.
Ⓐ, Ⓑ Increase in overall spinal canal area postoperatively after OLIF.
Spinal canal area.
Group 1 had 25 segments of 21 patients. Group 2 had 16 segments of 16 patients. Radiologically group 1 had spinal canal area improvement of 26.57% whereas group 2 had spinal canal area improvement of 72.78% (Table 4). Clinically all the patients of group (100%) showed excellent to good outcome, as per Modified Macnab’s criteria. Amongst group 2 patients, only 1 patient (6.25%) showed fair outcome whereas the rest of the patients (93.75%) showed excellent to good outcome as per Modified Macnab’s criteria.
Segments on MRI as per Schizas grade
Case Example
Fifty years old male patient presented with complaints of lower limb (right>left) neurogenic claudication for more than a year. Walking distance was<500 meters. Standing time was 5 minutes. There was no resting pain. Examination showed normal neurology. Radiology showed degenerative spondylolisthesis at L3-4 and L4-5 levels with lumbar canal stenosis on MRI (Schizas grade B at L3-4 and grade C at L4-5). Minimal access OLIF was performed at both the levels and posterior percutaneous fixation was done. The patient clinically improved and resumed his normal activities within 3 weeks. Clinically the patient showed Macnab grade A improvement. Also there was radiological improvement in foraminal height, disc height, spinal canal area and segmental lordosis postoperatively (Fig. 8).
Ⓐ Preoperative LS Spine Lateral X-ray. Ⓑ Preoperative LS Spine T2W sagittal MRI showing stenosis at L3-4 and L4-5. Ⓔ and Ⓕ Axial T2W MRI shows stenosis at L3-4 and L4-5 levels with subluxated facets at L3-4. Ⓒ and Ⓓ Postoperative Lateral X-ray and T2W sagittal MRI shows restoration of disc height, foraminal height and segmental lordosis at operated levels as compared to preoperative images. Ⓖ and Ⓗ Postoperative T2W axial MRI shows increase in the overall spinal canal area compared to preoperative images as well as cage positioning.
DISCUSSION
The current study shows the efficacy of OLIF to achieve indirect neural decompression in degenerative lumbar spine. The study included patients of degenerative lumbar spine disorders who had symptoms of neurologic claudication. None of them had rest pain. None of the patients were clinically positive for signs of nerve root tension. None required direct decompression. Excellent to good clinical results were achieved in 98% of the patients, while 1 had fair result. This patient had developed contralateral radiculopathy postoperatively due to cage malposition. Although he developed opposite sided leg pain, he was free from preoperative symptoms of neurogenic claudication. Radiologically there were improvements in disc height (92.1%), foraminal height (26.27%), spinal canal area (42.7%), and segmental lordosis (3.4°) which was statistically significant. These results show that in these patients direct decompression could be avoided and so all the potential complications of directdecompression like amount of back pain pertaining to muscle dissection or bony resection of lamina and facets, bleeding, nerve root injuries, dural tear, epidural bleeding, hematoma, deep wound infection etc., were avoided.
The concept of indirect neural decompression was introduced via ALIF procedure in patients of lumbar disc herniation [7]. There have been numerous other articles published as well which state that indirect neural decompression which can be achieved through ALIF, OLIF or LLIF/XLIF is beneficial in degenerative unstable lumbar spine disorders [8-17]. However none of these studies has defined the amount of radiological indirect decompression required for clinical improvement of patients as well as its limitations. The placement of the larger interbody cages through anterior approach is at the center of the philosophy of indirect decompression. It leads to better restoration of the disc height, unbuckling and stretching of the ligamentum flavum, foraminal opening and reduction of the posterior disc bulge which in turn decompresses the neural structures [26]. However this doesn’t cause direct thinning of the ligamentum flavum. It is known that unstable spine leads to cascade of degenerative changes affecting the spinal structures and also thickening of the ligamentum flavum. Sehji Ohtori et al. [26] in their study of 10 years follow-up of ALIF patients showed that stabilization of unstable spine leads to remodeling of spine and ligamentum flavum as well. All the segments, included in their study, had reduced thickness of ligamentum flavum as compared to immediate postop period, and spinal canal area was also larger.
As discussed earlier, all the anterior approaches including XLIF, ALIF, and OLIF allow placement of larger interbody cages as compared to posterior approaches. This leads to greater restoration of disc height and thus indirectly decompresses the spinal canal. Groth et al. [27] described similar changes after PLIF/TLIF cages. In their study, the maximum restoration of the disc height was 30% which is lesser than what can be achieved through anterior approaches. Another potential advantage of larger cage is that it spans the vertebral endplate and rests on cortical rim whereas smaller posterior cage rests on cancellous bone surface and will have higher rates of cage sinkage which is particularly of concern in osteoporotic bones [8].
Various studies have shown efficacy of indirect neural decompression by analyzing clinical as well as radiological outcomes (Table 5).
Various studies showing efficacy of indirect decompression
Above table shows in our study that we could achieve better indirect decompression in terms of better radiological outcomes. All the patients were benefited with indirect decompression except in the series of Oliveira et al., two patients had requirement of direct decompression. This was observed because of loss of disc height secondary to cage subsidence due to stand alone cages. However, it is general recommendation to supplement the fixation to cage placement to avoid cage subsidence [31].
Another important question is the limitation of indirect decompression. In our study we counselled the patients preoperatively regarding the need of direct decompression in case of unresolved symptoms. Many times the patients do not show clinical symptoms as per the amount of stenosis seen radiologically or vice versa. So it is difficult to judge how much radiological indirect decompression is required for given patient. To find out if there is any correlation with amount of indirect decompression and clinical improvement, we had divided our patients into two groups, based on Schizas grading of lumbar canal stenosis. Group 1 with class A and B patients showed less improvement radiologically in spinal canal area postoperatively as compared to group 2 who had class C and D patients. However, clinically both the groups showed excellent to good outcomes. Authors tended to avoid this procedure in patients of Schizas grade D stenosis, except for 4 cases.
There were several limitations of our study. The sample size was smaller. Also, it being a retrospective study, there was selection bias regarding whom we chose for the procedure. We were inclined to avoiding OLIF in patients having severe lumbar canal stenosis (Schizas grade D) and listhesis grade 3 or more. Long term follow-up is mandatory for the evaluation of maintenance of reduction and clinical improvement apart from fusion status.
CONCLUSION
* OLIF is an effective means of indirect decompression in degenerative lumbar spine disease.
* Clinically and radiologically, there was statistically significant improvement postoperatively after indirect decompression.
* It cannot be proven from this study whether indirect decompression is effective for patients with Schizas grade D stenosis.
* None of the patients in this study required direct decompression after OLIF.